TargetMol

360A

Product Code:
 
TAR-T7409
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T7409-1mg1mg£148.00
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TAR-T7409-2mg2mg£193.00
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TAR-T7409-5mg5mg£248.00
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TAR-T7409-10mg10mg£341.00
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TAR-T7409-25mg25mg£519.00
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TAR-T7409-50mg50mg£701.00
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TAR-T7409-100mg100mg£970.00
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Further Information

Bioactivity:
360A is a stabilizing G-Quadruplex ligand, and also inhibits telomerase activity for telomerase in TRAP-G4 assay(IC50 : 300 nM).
CAS:
794458-56-3
Formula:
C27H23N5O2
Molecular Weight:
449.513
Pathway:
DNA Damage/DNA Repair; Cell Cycle/Checkpoint
Purity:
0.98
SMILES:
C[n+]1cc(NC(=O)c2cccc(n2)C(=O)Nc2c[n+](C)c3ccccc3c2)cc2ccccc12
Target:
DNA/RNA Synthesis; Telomerase

References

Liu T, Wu Y, Qin L, et al.Nonselective Intercalation of G-Quadruplex-Targeting Ligands into Double-Stranded DNA Quantified by Single-Molecule Stretching.The Journal of Physical Chemistry B.2023 Hwang I , Mailliet P , Hossard V , et al. Investigating the Effect of Mono- and Dimeric 360A G-Quadruplex Ligands on Telomere Stability by Single Telomere Length Analysis (STELA)[J]. Molecules, 2019, 24(3). Pennarun Ga?lle, Christine G , Hoffschir Fran?oise, et al. Role of ATM in the telomere response to the G-quadruplex ligand 360A[J]. Nucleic Acids Research(5):5.