TargetMol

Ixabepilone

Product Code:
 
TAR-T6864
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T6864-1mg1mg£112.00
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TAR-T6864-2mg2mg£146.00
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TAR-T6864-5mg5mg£230.00
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TAR-T6864-1mL1 mL * 10 mM (in DMSO)£254.00
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TAR-T6864-10mg10mg£362.00
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TAR-T6864-25mg25mg£544.00
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TAR-T6864-50mg50mg£759.00
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TAR-T6864-100mg100mg£994.00
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TAR-T6864-200mg200mg£1,315.00
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This product comes from: United States.
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Further Information

Bioactivity:
Ixabepilone is an orally bioavailable microtubule inhibitor. It binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arresting cells in the G2-M phase of the cell cycle and inducing tumor cell apoptosis.
CAS:
219989-84-1
Formula:
C27H42N2O5S
Molecular Weight:
506.7
Pathway:
Apoptosis; Cytoskeletal Signaling
Purity:
0.986
SMILES:
C[C@H]1CCC[C@@]2([C@@H](O2)C[C@H](NC(=O)C[C@@H](C(C(=O)[C@@H]([C@H]1O)C)(C)C)O)/C(=C/C3=CSC(=N3)C)/C)C
Target:
Apoptosis; Microtubule Associated

References

Wang D, Wang Y, Di X, et al.Cortical tension drug screen links mitotic spindle integrity to Rho pathway.Current Biology.2023 Wang M, Wang J, Tsui A Y P, et al. Mechanisms of peripheral neurotoxicity associated with four chemotherapy drugs using human induced pluripotent stem cell-derived peripheral neurons. Toxicology in Vitro. 2021: 105233. Lee FY, et al. Clin Cancer Res. 2001, 7(5):1429-1437.