TargetMol

Endoxifen Z-isomer hydrochloride

Product Code:
 
TAR-T6827
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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Further Information

Bioactivity:
Endoxifen HCl is the active metabolite of Tamoxifen, which is an effective and selective estrogen receptor antagonist.
CAS:
1032008-74-4
Formula:
C25H28ClNO2
Molecular Weight:
409.95
Pathway:
JAK/STAT signaling; Tyrosine Kinase/Adaptors; Endocrinology/Hormones; Membrane transporter/Ion channel; Angiogenesis
Purity:
0.98
SMILES:
Cl.CCC(=C(/c1ccc(O)cc1)c1ccc(OCCNC)cc1)c1ccccc1
Target:
Estrogen Receptor/ERR; Potassium Channel; Estrogen/progestogen Receptor; HER

References

Chae YJ, et al. Eur J Pharmacol. 2015, 752, 1-7. Li J, Yu F, Guo H, et al. Crystal structure of plant PLD?1 reveals catalytic and regulatory mechanisms of eukaryotic phospholipase D[J]. Cell Research. 2020, 30(1): 61-69. Wu X, et al. Cancer Res. 2009, 69(5), 1722-1727. Lim YC, et al. Cancer Chemother Pharmacol. 2005, 55(5), 471-478. Ahmad A, et al. Breast Cancer Res Treat. 2010, 122(2), 579-584. Ali SM, et al. Bioorg Med Chem Lett. 2010, 20(8), 2665-2667. Wang K, Chen Y, Gao S, et al. Norlichexanthone purified from plant endophyte prevents postmenopausal osteoporosis by targeting ER? to inhibit RANKL signaling[J]. Acta Pharmaceutica Sinica B. 2020 Li J, Yu F, Guo H, et al. Crystal structure of plant PLD?1 reveals catalytic and regulatory mechanisms of eukaryotic phospholipase D. Cell Research. 2020, 30(1): 61-69.