TargetMol

Sotrastaurin

Product Code:
 
TAR-T6278
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T6278-1mg1mg£107.00
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TAR-T6278-5mg5mg£148.00
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TAR-T6278-1mL1 mL * 10 mM (in DMSO)£164.00
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TAR-T6278-10mg10mg£206.00
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TAR-T6278-25mg25mg£335.00
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TAR-T6278-50mg50mg£539.00
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TAR-T6278-100mg100mg£739.00
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TAR-T6278-500mg500mg£1,404.00
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This product comes from: United States.
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Further Information

Bioactivity:
Sotrastaurin is a potent pan-PKC inhibitor (Kis: 0.95/0.64/2.1/3.2/1.8/0.22 nM for PKCα/βI/δ/ε/?/?).
CAS:
425637-18-9
Formula:
C25H22N6O2
Molecular Weight:
438.491
Pathway:
Cytoskeletal Signaling; Chromatin/Epigenetic
Purity:
0.9943
SMILES:
CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc2n1
Target:
PKC

References

Evenou JP, et al. The potent protein kinase C-selective inhibitor AEB071 (sotrastaurin) represents a new class of immunosuppressive agents affecting early T-cell activation. J Pharmacol Exp Ther. 2009 Sep;330(3):792-801. Naylor TL, et al. Protein kinase C inhibitor sotrastaurin selectively inhibits the growth of CD79 mutant diffuse large B-cell lymphomas. Cancer Res. 2011 Apr 1;71(7):2643-53. Musi E, et al. The phosphoinositide 3-kinase ? selective inhibitor BYL719 enhances the effect of the protein kinase C inhibitor AEB071 in GNAQ/GNA11-mutant uveal melanoma cells. Mol Cancer Ther. 2014 May;13(5):1044-53.