TargetMol

Trichostatin A

Product Code:
 
TAR-T6270
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T6270-1mg1mg£140.00
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TAR-T6270-2mg2mg£160.00
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TAR-T6270-1mL1 mL * 10 mM (in DMSO)£217.00
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TAR-T6270-5mg5mg£229.00
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TAR-T6270-10mg10mg£370.00
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TAR-T6270-25mg25mg£490.00
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TAR-T6270-50mg50mg£677.00
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Further Information

Bioactivity:
Trichostatin A is a natural derivative of dienohydroxamic acid isolated from species of the bacterial genus Streptomyces. Trichostatin A (TSA) reversibly and specifically inhibits histone deacetylases, resulting in hyperacetylation of core histones which modulate chromatin structure. The increase in histone acetylation promotes selective gene transcription and the inhibition of tumor growth. This agent is a potent inducer of tumor cell growth arrest, differentiation and apoptosis in a variety of transformed cells in culture and in tumor-bearing animals.
CAS:
58880-19-6
Formula:
C17H22N2O3
Molecular Weight:
302.374
Pathway:
Chromatin/Epigenetic; DNA Damage/DNA Repair
Purity:
0.9805
SMILES:
C[C@H](C=C(/C)C=CC(=O)NO)C(=O)c1ccc(cc1)N(C)C
Target:
HDAC

References

Xu K, Sun G, Li M, et al. Glibenclamide Targets Sulfonylurea Receptor 1 to Inhibit p70S6K Activity and Upregulate KLF4 Expression to Suppress Non-Small Cell Lung Carcinoma. Molecular cancer therapeutics. 2019, 18(11): 2085-2096. Zhang L, Shi J, Du D, et al. Ketogenesis acts as an endogenous protective programme to restrain inflammatory macrophage activation during acute pancreatitis. eBioMedicine. 2022, 78: 103959. Li X, Pan L, Wang B, et al. The Histone Deacetylases HosA and HdaA Affect the Phenotype and Transcriptomic and Metabolic Profiles of Aspergillus niger. Toxins. 2019, 11(9): 520. Su Q, Li T, He P F, et al. Trichostatin A ameliorates Alzheimer?s disease-related pathology and cognitive deficits by increasing albumin expression and A? clearance in APP/PS1 mice[J]. Alzheimer's Research & Therapy. 2021, 13(1): 1-15. Su Q, Li T, He P F, et al. Trichostatin A ameliorates Alzheimer?s disease-related pathology and cognitive deficits by increasing albumin expression and A? clearance in APP/PS1 mice. Alzheimer's Research & Therapy. 2021 Jan 4;13(1):7. doi: 10.1186/s13195-020-00746-8. Huang W, et al. J Biol Chem, 2005, 280(11), 120047-120054. Kim MS, et al. Cancer Res, 2003, 63(21), 7291-7300. Yuting Meng,Xixi Qian,Li Zhao,Nan Li,Shengjie Wu,Baoan Chen,Tong Sun,Xuerong Wang Trichostatin A downregulates bromodomain and extra-terminal proteins to suppress osimertinib resistant non-small cell lung carcinoma. Cancer Cell International. 2021, 21(1): 1-12. Wang C, Huang M, Lin Y, et al.ENO2-derived phosphoenolpyruvate functions as an endogenous inhibitor of HDAC1 and confers resistance to antiangiogenic therapy.Nature Metabolism.2023: 1-22. Guo Q, Jing Y, Gao Y, et al.The PIF1/PIF3?MED25?HDA19 transcriptional repression complex regulates phytochrome signaling in Arabidopsis.New Phytologist.2023 Furumai R, et al. Proc Natl Acad Sci U S A, 2001, 98(1), 87-92. Li X, Pan L, Wang B, et al. The Histone Deacetylases HosA and HdaA Affect the Phenotype and Transcriptomic and Metabolic Profiles of Aspergillus niger[J]. Toxins. 2019, 11(9): 520. Vigushin DM, et al. Clin Cancer Res, 2001, 7(4), 971-976. Liang X L, Ouyang L, Yu N N, et al.Histone deacetylase inhibitor pracinostat suppresses colorectal cancer by inducing CDK5-Drp1 signaling-mediated peripheral mitofission.Journal of Pharmaceutical Analysis.2023 Xu K, Sun G, Li M, et al. Glibenclamide Targets Sulfonylurea Receptor 1 to Inhibit p70S6K Activity and Upregulate KLF4 Expression to Suppress Non-Small Cell Lung Carcinoma[J]. Molecular cancer therapeutics. 2019, 18(11): 2085-2096. Avila AM, et al. J Clin Invest, 2007, 117(3), 659-671. Meng Y, Qian X, Zhao L, et al. Trichostatin A downregulates bromodomain and extra-terminal proteins to suppress osimertinib resistant non-small cell lung carcinoma[J]. Cancer Cell International. 2021, 21(1): 1-12.