TargetMol

Loureirin A

Product Code:
 
TAR-T5S0896
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T5S0896-1mg1mg£125.00
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TAR-T5S0896-5mg5mg£189.00
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TAR-T5S0896-1mL1 mL * 10 mM (in DMSO)£246.00
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TAR-T5S0896-10mg10mg£246.00
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TAR-T5S0896-25mg25mg£367.00
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TAR-T5S0896-50mg50mg£507.00
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TAR-T5S0896-100mg100mg£694.00
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TAR-T5S0896-500mg500mg£1,332.00
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Further Information

Bioactivity:
Loureirin A has an inhibitory effect on platelet activation, perhaps through an impairment of PI3K/Akt signaling.Loureirin A negatively affects agonist-induced platelet aggregation such as collagen, collagen-related peptide (CRP), ADP and thrombin. Loureirin A activates Wnt/-catenin pathway and promotes hair follicle stem cells (FSCs)-seeded tissue-engineered skin to repair skin wound.The molecular mechanism of Loureirin A and Wnt signaling pathway mediated anti- hepatic fibrosis and anti- angiogenesis may involve down- regulation the expression of Frizzled- 4,inhibiting the synthesis and secretion of α- SMA,TGF- β1and the proliferation of HSCs.
CAS:
119425-89-7
Formula:
C17H18O4
Molecular Weight:
286.327
Pathway:
Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
Purity:
0.9984
SMILES:
COc1ccc(CCC(=O)c2ccc(O)cc2)c(OC)c1
Target:
Akt; PI3K

References

Hao H Z, He A D, Wang D C, et al. Antiplatelet activity of loureirin A by attenuating Akt phosphorylation: In vitro studies[J]. European Journal of Pharmacology, 2015, 746:63-69.