TargetMol

A1874

Product Code:
 
TAR-T5442
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T5442-1mg1mg£254.00
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TAR-T5442-2mg2mg£325.00
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TAR-T5442-5mg5mg£462.00
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TAR-T5442-10mg10mg£625.00
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TAR-T5442-25mg25mg£946.00
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Quantity:
TAR-T5442-50mg50mg£1,251.00
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Quantity:
TAR-T5442-100mg100mg£1,661.00
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Quantity:
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
A1874 is a nutlin-based and BRD4-degrading PROTAC which induces BRD4 degradation in cells. Effective in inhibiting many cancer cell lines proliferation.
CAS:
2064292-12-0
Formula:
C58H62Cl3F2N9O7S
Molecular Weight:
1173.6
Pathway:
Chromatin/Epigenetic
Purity:
0.98
SMILES:
COc1cc(ccc1NC(=O)C1NC(CC(C)(C)C)C(C#N)(C1c1cccc(Cl)c1F)c1ccc(Cl)cc1F)C(=O)NCCOCCOCCOCCNC(=O)CC1N=C(c2c(C)c(C)sc2-n2c(C)nnc12)c1ccc(Cl)cc1
Target:
Epigenetic Reader Domain

References

Hines J, Lartigue S, Dong H.et.al.MDM2-Recruiting PROTAC Offers Superior, Synergistic Antiproliferative Activity via Simultaneous Degradation of BRD4 and Stabilization of p53[J].Cancer Res. 2019 Jan 1;79(1):251-262.