TargetMol

ARV-825

Product Code:
 
TAR-T5434
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T5434-1mg1mg£119.00
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TAR-T5434-5mg5mg£189.00
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TAR-T5434-10mg10mg£213.00
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TAR-T5434-1mL1 mL * 10 mM (in DMSO)£254.00
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TAR-T5434-25mg25mg£294.00
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TAR-T5434-50mg50mg£369.00
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Quantity:
TAR-T5434-100mg100mg£517.00
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Further Information

Bioactivity:
ARV-825, a heterobifunctional PROTAC (Proteolysis Targeting Chimera) that recruits BRD4 to the E3 ubiquitin ligase cereblon leading to fast, efficient, and prolonged degradation of BRD4 in all BL cell lines tested.
CAS:
1818885-28-7
Formula:
C46H47ClN8O9S
Molecular Weight:
923.44
Pathway:
Chromatin/Epigenetic
Purity:
0.98
SMILES:
Cc1sc-2c(c1C)C(=N[C@@H](CC(=O)Nc1ccc(OCCOCCOCCOCCNc3cccc4C(=O)N(C5CCC(=O)NC5=O)C(=O)c34)cc1)c1nnc(C)n-21)c1ccc(Cl)cc1
Target:
Epigenetic Reader Domain

References

Lu J, et al. Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4. Chem Biol. 2015 Jun 18;22(6):755-63.