TargetMol

IACS-010759

Product Code:
 
TAR-T5337
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T5337-1mg1mg£108.00
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TAR-T5337-2mg2mg£124.00
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TAR-T5337-5mg5mg£163.00
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TAR-T5337-1mL1 mL * 10 mM (in DMSO)£193.00
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TAR-T5337-10mg10mg£213.00
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TAR-T5337-25mg25mg£369.00
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TAR-T5337-50mg50mg£503.00
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TAR-T5337-100mg100mg£703.00
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TAR-T5337-200mg200mg£930.00
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Further Information

Bioactivity:
IACS-010759 is an orally bioavailable inhibitor of complex I of oxidative phosphorylation of the mitochondrial electron transport chain.
CAS:
1570496-34-2
Formula:
C25H25F3N6O4S
Molecular Weight:
562.57
Pathway:
Metabolism; Apoptosis;
Purity:
0.9983
SMILES:
Cc1nc(nn1Cc1cccc(c1)N1CCC(CC1)S(C)(=O)=O)-c1nc(no1)-c1ccc(OC(F)(F)F)cc1
Target:
Apoptosis; Mitochondrial Metabolism

References

Lissanu Deribe Y, et al. Mutations in the SWI/SNF complex induce a targetable dependence on oxidative phosphorylation in lung cancer. Nat Med. 2018 Jul;24(7):1047-1057. Molina JR, et al. An inhibitor of oxidative phosphorylation exploits cancer vulnerability. Nat Med. 2018 Jul;24(7):1036-1046. Vangapandu HV, et al. Biological and metabolic effects of IACS-2010759, an OxPhos inhibitor, on chronic lymphocytic leukemia cells. Oncotarget. 2018 May 18;9(38):24980-241991. Ren L, Meng L, Gao J, et al.PHB2 promotes colorectal cancer cell proliferation and tumorigenesis through NDUFS1-mediated oxidative phosphorylation.Cell Death & Disease.2023, 14(1): 44.