TargetMol

Danirixin

Product Code:
 
TAR-T5193
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T5193-1mg1mg£135.00
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TAR-T5193-5mg5mg£269.00
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TAR-T5193-1mL1 mL * 10 mM (in DMSO)£294.00
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TAR-T5193-10mg10mg£350.00
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TAR-T5193-25mg25mg£543.00
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TAR-T5193-50mg50mg£744.00
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TAR-T5193-100mg100mg£1,002.00
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TAR-T5193-500mg500mg£1,934.00
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This product comes from: United States.
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Further Information

Bioactivity:
Danirixin is a potent antagonist of CXCR2 that inhibits IL-8 binding to CXCR2 (IC50: 12.5 nM).
CAS:
954126-98-8
Formula:
C19H21ClFN3O4S
Molecular Weight:
441.9
Pathway:
Autophagy; GPCR/G Protein; Immunology/Inflammation
Purity:
0.9978
SMILES:
Cc1c(F)cccc1NC(=O)Nc1ccc(Cl)c(c1O)S(=O)(=O)[C@H]1CCCNC1
Target:
CXCR

References

Miller BE, et al. The pharmacokinetics and pharmacodynamics of danirixin (GSK1325756)--a selective CXCR2 antagonist --in healthy adult subjects. BMC Pharmacol Toxicol. 2015 Jun 20;16:18. Miller BE, et al. The pharmacokinetics of conventional and bioenhanced tablet formulations of danirixin (GSK1325756) following oral administration in healthy, elderly, human volunteers. Eur J Drug Metab Pharmacokinet. 2014 Sep;39(3):173-81.