TargetMol

SRT 1720 dihydrochloride[925434-55-5(free base)]

Product Code:
 
TAR-T5124
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T5124-1mg1mg£115.00
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TAR-T5124-2mg2mg£132.00
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TAR-T5124-5mg5mg£157.00
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TAR-T5124-10mg10mg£209.00
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TAR-T5124-25mg25mg£307.00
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TAR-T5124-50mg50mg£449.00
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Quantity:
TAR-T5124-100mg100mg£623.00
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Further Information

Bioactivity:
SRT 1720 is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2 (EC1.5: 37 μM) and SIRT3 (EC1.5: 300 μM).
CAS:
T5124
Formula:
C25H25Cl2N7OS
Molecular Weight:
542.48
Pathway:
Chromatin/Epigenetic; DNA Damage/DNA Repair
Purity:
0.9858
SMILES:
Cl.Cl.O=C(Nc1ccccc1-c1cn2c(CN3CCNCC3)csc2n1)c1cnc2ccccc2n1
Target:
Sirtuin

References

Baur JA, et al. Are sirtuins viable targets for improving healthspan and lifespan?,Nat Rev Drug Discov. 2012 Jun 1;11(6):443-61 Gao D, et al. Activation of SIRT1 Attenuates Klotho Deficiency-Induced Arterial Stiffness and Hypertension by Enhancing AMP-Activated Protein Kinase Activity. Hypertension. 2016 Nov;68(5):1191-1199. Milne JC et al. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature. 2007 Nov 29;450(7170):712-6 Yao H, et al. SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice.,J Clin Invest. 2012 Jun 1;122(6):2032-45.