TargetMol

NVP-BSK805

Product Code:
 
TAR-T5049
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T5049-1mg1mg£116.00
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TAR-T5049-5mg5mg£177.00
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TAR-T5049-10mg10mg£247.00
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TAR-T5049-25mg25mg£417.00
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This product comes from: United States.
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Further Information

Bioactivity:
NVP-BSK805 is an ATP-competitive JAK2 inhibitor.
CAS:
1092499-93-8
Formula:
C27H28F2N6O
Molecular Weight:
490.559
Pathway:
Tyrosine Kinase/Adaptors; Chromatin/Epigenetic; Stem Cells; JAK/STAT signaling; Angiogenesis
Purity:
0.98
SMILES:
Fc1cc(cc(F)c1CN1CCOCC1)-c1cccc2ncc(nc12)-c1cnn(c1)C1CCNCC1
Target:
Tyrosine Kinases; JAK

References

Baffert F, et al. Potent and selective inhibition of polycythemia by the quinoxaline JAK2 inhibitor NVP-BSK805. Mol Cancer Ther. 2010 Jul;9(7):1945-55. Cheon JH, et al. The JAK2 inhibitors CEP-33779 and NVP-BSK805 have high P-gp inhibitory activity and sensitize drug-resistant cancer cells to vincristine. Biochem Biophys Res Commun. 2017 Sep 2;490(4):1176-1182. Rubert J, et al. BMC Cancer, 2011, Jan(19), 11-24.