TargetMol

Cariprazine

Product Code:
 
TAR-T4577
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4577-1mg1mg£108.00
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TAR-T4577-2mg2mg£128.00
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TAR-T4577-1mL1 mL * 10 mM (in DMSO)£159.00
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TAR-T4577-5mg5mg£159.00
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TAR-T4577-10mg10mg£222.00
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TAR-T4577-25mg25mg£338.00
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TAR-T4577-50mg50mg£470.00
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TAR-T4577-100mg100mg£627.00
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Further Information

Bioactivity:
Cariprazine is a novel antipsychotic drug candidate that exhibits high affinity for the D3 (Ki=0.085 nM) and D2 (Ki=0.49 nM) receptors, and moderate affinity for the 5-HT1A receptor (Ki=2.6 nM).
CAS:
839712-12-8
Formula:
C21H32Cl2N4O
Molecular Weight:
427.41
Pathway:
Neuroscience; GPCR/G Protein
Purity:
0.9975
SMILES:
CN(C)C(=O)N[C@H]1CC[C@H](CCN2CCN(CC2)c2cccc(Cl)c2Cl)CC1
Target:
Dopamine Receptor; 5-HT Receptor

References

Zimnisky R,etal.Cariprazine, a dopamine D(3)-receptor-preferring partial agonist, blocks phencyclidine-induced impairments of working memory, attention set-shifting, and recognition memory in the mouse.Psychopharmacology (Berl). 2013 Mar;226(1):91-100. Gao Y,etal.Cariprazine exerts antimanic properties and interferes with dopamine D2 receptor ?-arrestin interactions. Pharmacol Res Perspect. 2015 Feb;3(1):e00073. Seneca N,etal.Occupancy of dopamine D? and D? and serotonin 5-HT?A receptors by the novel antipsychotic drug candidate, cariprazine (RGH-188), in monkey brain measured using positron emission tomography. Psychopharmacology (Berl). 2011 Dec;218(3):579-87. Kiss B,etal.Cariprazine (RGH-188), a dopamine D(3) receptor-preferring, D(3)/D(2) dopamine receptor antagonist-partial agonist antipsychotic candidate: in vitro and neurochemical profile.J Pharmacol Exp Ther. 2010 Apr;333(1):328-40.