TargetMol

ADX88178

Product Code:
 
TAR-T4500
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4500-1mg1mg£101.00
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TAR-T4500-2mg2mg£114.00
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TAR-T4500-5mg5mg£142.00
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TAR-T4500-1mL1 mL * 10 mM (in DMSO)£144.00
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TAR-T4500-10mg10mg£189.00
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TAR-T4500-25mg25mg£282.00
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TAR-T4500-50mg50mg£412.00
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TAR-T4500-100mg100mg£571.00
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Further Information

Bioactivity:
ADX88178 is a potent positive allosteric modulator for metabotropic glutamate receptor 4 (mGluR4) with EC50 of 4 nM for human mGluR4.
CAS:
1235318-89-4
Formula:
C12H12N6S
Molecular Weight:
272.33
Pathway:
Neuroscience
Purity:
0.9926
SMILES:
Cc1sc(Nc2nccc(C)n2)nc1-c1cn[nH]c1
Target:
GluR

References

Fujinaga M, et al. Radiosynthesis and evaluation of 5-methyl-N-(4-[(11)C]methylpyrimidin-2-yl)-4-(1H-pyrazol-4-yl)thiazol-2-amine ([(11)C]ADX88178) as a novel radioligand for imaging of metabotropic glutamate receptor subtype 4 (mGluR4). Bioorg Med Chem Lett. 2016 Jan 15;26(2):370-4. Kalinichev M, et al. Characterization of the novel positive allosteric modulator of the metabotropic glutamate receptor 4 ADX88178 in rodent models of neuropsychiatric disorders. J Pharmacol Exp Ther. 2014 Sep;350(3):495-505. Ponnazhagan R, et al. The Metabotropic Glutamate Receptor 4 Positive Allosteric Modulator ADX88178 Inhibits Inflammatory Responses in Primary Microglia. J Neuroimmune Pharmacol. 2016 Jun;11(2):231-7.