TargetMol

E7449

Product Code:
 
TAR-T4471
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4471-1mg1mg£109.00
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TAR-T4471-2mg2mg£127.00
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TAR-T4471-5mg5mg£164.00
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TAR-T4471-1mL1 mL * 10 mM (in DMSO)£174.00
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TAR-T4471-10mg10mg£230.00
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TAR-T4471-25mg25mg£398.00
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TAR-T4471-50mg50mg£547.00
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TAR-T4471-100mg100mg£764.00
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Further Information

Bioactivity:
E7449 is a potent PARP1 and PARP2 inhibitor and also inhibits TNKS1 and TNKS2, with IC50s of 2.0, 1.0, ?50 and ?50 nM for PARP1, PARP2, TNKS1 and TNKS2, respectively, using 32P-NAD+ as substrate.
CAS:
1140964-99-3
Formula:
C18H15N5O
Molecular Weight:
317.352
Pathway:
DNA Damage/DNA Repair; Chromatin/Epigenetic;
Purity:
0.9713
SMILES:
O=c1[nH]nc2[nH]c(CN3Cc4ccccc4C3)nc3cccc1c23
Target:
PARP

References

McGonigle S, Chen Z, Wu J, et al. E7449: A dual inhibitor of PARP1/2 and tankyrase1/2 inhibits growth of DNA repair deficient tumors and antagonizes Wnt signaling. Oncotarget. 2015;6(38):41307-41323. doi:10.18632/oncotarget.5846