TargetMol

Porcn-IN-1

Product Code:
 
TAR-T4438
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4438-1mg1mg£111.00
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TAR-T4438-5mg5mg£168.00
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TAR-T4438-1mL1 mL * 10 mM (in DMSO)£177.00
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TAR-T4438-10mg10mg£230.00
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TAR-T4438-25mg25mg£348.00
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TAR-T4438-50mg50mg£485.00
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TAR-T4438-100mg100mg£662.00
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This product comes from: United States.
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Further Information

Bioactivity:
Porcupine-IN-1 is an effective porcupine inhibitor (IC50: 0.5?0.2 nM).
CAS:
2036044-77-4
Formula:
C25H19FN4O
Molecular Weight:
410.452
Pathway:
Stem Cells
Purity:
0.9961
SMILES:
Cc1cc(ccn1)-c1ncc(CNC(=O)c2ccc3c(c2)[nH]c2ccccc32)cc1F
Target:
Porcupine

References

Xu Z, Xu X, O?Laoi R, et al. Design, synthesis, and evaluation of novel porcupine inhibitors featuring a fused 3-ring system based on the ?reversed?amide scaffold[J]. Bioorganic & medicinal chemistry, 2016, 24(22): 5861-5872. Wu W, Xu H, Liao C, et al. Blockade of USP14 potentiates type I interferon signaling and radiation-induced antitumor immunity via preventing IRF3 deubiquitination. Cellular Oncology. 2022: 1-15 Yue X, Liu T, Wang X, et al.Pharmacological inhibition of BAP1 recruits HERC2 to competitively dissociate BRCA1?BARD1, suppresses DNA repair and sensitizes CRC to radiotherapy.Acta Pharmaceutica Sinica B.2023