TargetMol

AZD4635

Product Code:
 
TAR-T4265
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4265-1mg1mg£95.00
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TAR-T4265-2mg2mg£106.00
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TAR-T4265-5mg5mg£128.00
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TAR-T4265-1mL1 mL * 10 mM (in DMSO)£134.00
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TAR-T4265-10mg10mg£165.00
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TAR-T4265-25mg25mg£230.00
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TAR-T4265-50mg50mg£321.00
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TAR-T4265-100mg100mg£456.00
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TAR-T4265-500mg500mg£922.00
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Further Information

Bioactivity:
AZD4635 is a new-type adenosine 2A receptor (A2AR) inhibitor(Ki=1.7 nM).
CAS:
1321514-06-0
Formula:
C15H11ClFN5
Molecular Weight:
315.74
Pathway:
GPCR/G Protein; Neuroscience
Purity:
0.9961
SMILES:
Cc1cc(cc(Cl)n1)-c1nnc(N)nc1-c1ccc(F)cc1
Target:
Adenosine Receptor

References

Alexandra Borodovsky, et al. Abstract 5580: PreClinicalal pharmacodynamics and antitumor activity of AZD4635, a novel adenosine 2A receptor inhibitor that reverses adenosine mediated T cell suppression. AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 5580. Kang G, Zhao X, Sun J, et al.A2AR limits IL-15-induced generation of CD39+ NK cells with high cytotoxicity.International Immunopharmacology.2023, 114: 109567.