TargetMol

AFMK

Product Code:
 
TAR-T41345
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T41345-1mg1mg£117.00
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TAR-T41345-2mg2mg£142.00
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TAR-T41345-5mg5mg£173.00
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TAR-T41345-1mL1 mL * 10 mM (in DMSO)£180.00
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TAR-T41345-10mg10mg£230.00
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TAR-T41345-25mg25mg£330.00
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TAR-T41345-50mg50mg£455.00
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TAR-T41345-100mg100mg£621.00
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TAR-T41345-500mg500mg£1,259.00
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Further Information

Bioactivity:
AFMK is an active metabolite of Melatonin with antioxidant and free radical scavenging activity. AFMK is a modulator of apoptosis and improves the anti-tumor effect of Gemcitabine in PANC-1 cells.
CAS:
52450-38-1
Formula:
C13H16N2O4
Molecular Weight:
264.28
Pathway:
oxidation-reduction; Apoptosis; Metabolism
Purity:
0.9988
SMILES:
O=CNC1=CC=C(OC)C=C1C(=O)CCNC(=O)C
Target:
Apoptosis; Free radical scavengers; Antioxidant; Endogenous Metabolite

References

Annia Galano, et al. On the free radical scavenging activities of melatonin's metabolites, AFMK and AMK. J Pineal Res. 2013 Apr;54(3):245-57. Kailash Manda, et al. AFMK, a melatonin metabolite, attenuates X-ray-induced oxidative damage to DNA, proteins and lipids in mice. J Pineal Res. 2007 Apr;42(4):386-93. Anna Leja-Szpak, et al. Melatonin and its metabolite N1-acetyl-N2-formyl-5-methoxykynuramine (afmk) enhance chemosensitivity to gemcitabine in pancreatic carcinoma cells (PANC-1). Pharmacol Rep. 2018 Dec;70(6):1079-1088.