TargetMol

Deltonin

Product Code:
 
TAR-T3844
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T3844-1mg1mg£171.00
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TAR-T3844-5mg5mg£322.00
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TAR-T3844-10mg10mg£446.00
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TAR-T3844-1mL1 mL * 10 mM (in DMSO)£453.00
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TAR-T3844-25mg25mg£675.00
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TAR-T3844-50mg50mg£863.00
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Further Information

Bioactivity:
Deltonin has an inhibition of ERK1/2 and AKT activation. Deltonin shows cytotoxicity against human HepG2 cells (IC50: 7.66 μM), mouse C26 cells (IC50: 1.22 μM), and human MDA-MB-231 cells (IC50: 1.58 μM).
CAS:
55659-75-1
Formula:
C45H72O17
Molecular Weight:
885.054
Pathway:
MAPK; PI3K/Akt/mTOR signaling; ; Cytoskeletal Signaling; Metabolism
Purity:
0.9979
SMILES:
C[C@H]1[C@H]2[C@H](C[C@H]3[C@@H]4CC=C5C[C@H](CC[C@]5(C)[C@H]4CC[C@]23C)O[C@@H]2O[C@H](CO)[C@@H](O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)[C@H](O)[C@H]2O[C@@H]2O[C@@H](C)[C@H](O)[C@@H](O)[C@H]2O)O[C@]11CC[C@@H](C)CO1
Target:
ERK; Akt; Endogenous Metabolite

References

Zhang S, et al. Deltonin induces apoptosis in MDA?MB?231 human breast cancer cells via reactive oxygen species?mediated mitochondrial dysfunction and ERK/AKT signaling pathways. Mol Med Rep. 2013 Mar;7(3):1038-44. Tong QY, et al. Deltonin, a steroidal saponin, inhibits colon cancer cell growth in vitro and tumor growth in vivo via induction of apoptosis and antiangiogenesis. Cell Physiol Biochem. 2011;27(3-4):233-42.