TargetMol

21-Deoxycortisol

Product Code:
 
TAR-T36915
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T36915-1mg1mg£112.00
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TAR-T36915-5mg5mg£192.00
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TAR-T36915-10mg10mg£294.00
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TAR-T36915-25mg25mg£463.00
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Further Information

Bioactivity:
21-Deoxycortisol is a corticosteroid metabolite of 17-hydroxyprogesterone produced in the adrenal glandvia11-hydroxylation by 11β-hydroxylase.1,2Serum levels of 21-deoxycortisol are elevated in patients with congenital adrenal hyperplasia that are heterozygous for mutations inCYP2A21, the gene encoding steroid 21-hydroxylase, and have been used as a biomarker for the detection of 21-hydroxylase deficiencies.
CAS:
641-77-0
Formula:
C12H10Br2Cl2N4O8S
Molecular Weight:
601
Purity:
0.98
SMILES:
[O-]S([O-])(=O)=O.[NH3+]c1c(Cl)cc(cc1Br)[N+]([O-])=O.[NH3+]c1c(Cl)cc(cc1Br)[N+]([O-])=O

References

Cristoni, S., Cuccato, D., Sciannamblo, M., et al.Analysis of 21-deoxycortisol, a marker of congenital adrenal hyperplasia, in blood by atmospheric pressure chemical ionization and electrospray ionization using multiple reaction monitoringRapid Commun. Mass Spectrom.18(1)77-82(2004) Fiet, J., Villette, J.-M., Galons, H., et al.The application of a new highly-sensitive radioimmunoassay for plasma 21-deoxycortisol to the detection of steroid-21-hydroxylase deficiencyAnn. Clin. Biochem.31(Pt. 1)56-64(1994)