TargetMol

(E)-2-(2-Chlorostyryl)-3,5,6-trimethylpyrazine

Product Code:
 
TAR-T36610
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T36610-1mg1mg£99.00
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TAR-T36610-5mg5mg£185.00
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TAR-T36610-10mg10mg£287.00
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TAR-T36610-25mg25mg£539.00
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This product comes from: United States.
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Further Information

Bioactivity:
(E)-2-(2-Chlorostyryl)-3,5,6-trimethylpyrazine (CSTMP) is a stilbene derivative with antioxidant and anticancer activities. It stimulates proliferation of hydrogen peroxide-damaged ECV-304 cells (EC50 = 24.9 nM). CSTMP reduces hydrogen peroxide-induced release of lactate dehydrogenase (LDH) in and increases viability of human umbilical vein endothelial cells (HUVECs) in a concentration-dependent manner via inhibition of apoptosis. It reverses hydrogen peroxide-induced release of malondialdehyde (MDA) and decreases in superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities as well as increases constitutive nitric oxide synthase (cNOS) activity and nitric oxide (NO) production in HUVECs. CSTMP also induces cell death of A549 non-small cell lung cancer (NSCLC) cells in an IRE1α-dependent manner through induction of IRE1α-TRAF2-ASK1 complex-mediated endoplasmic reticulum (ER) stress and mitochondrial apoptosis.
CAS:
1000672-89-8
Formula:
C15H15ClN2
Molecular Weight:
258.8
Purity:
0.98
SMILES:
CC1=C(C)N=C(C)C(/C=C/C2=CC=CC=C2Cl)=N1