TargetMol

(S)-nitro-Blebbistatin

Product Code:
 
TAR-T36335
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T36335-1mg1mg£187.00
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TAR-T36335-5mg5mg£545.00
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TAR-T36335-10mg10mg£820.00
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TAR-T36335-25mg25mg£1,321.00
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Further Information

Bioactivity:
(S)-nitro-Blebbistatin is a more stable form of (-)-blebbistatin , which is a selective cell-permeable inhibitor of non-muscle myosin II ATPases. (-)-Blebbistatin rapidly and reversibly inhibits Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB for several species (IC50s = 0.5-5 μM), while poorly inhibiting smooth muscle myosin (IC50 = 80 μM). Through these effects, it blocks apoptosis-related bleb formation, directed cell migration, and cytokinesis in vertebrate cells. However, prolonged exposure to blue light (450-490 nm) results in degradation of blebbistatin to an inactive product via cytotoxic intermediates, which may be problematic for its use in fluorescent live cell imaging applications. The addition of a nitro group stabilizes the molecule to circumvent its degradation by prolonged blue light exposure. (S)-nitro-Blebbistatin has the same stereochemistry as the active (-)-blebbistatin enantiomer.
CAS:
856925-75-2
Formula:
C17H13N3O4
Molecular Weight:
323.308
Purity:
0.98
SMILES:
O[C@@]12CCN(C1=Nc1cc(ccc1C2=O)[N+]([O-])=O)c1ccccc1