TargetMol

C8 D-threo Ceramide (d18:1/8:0)

Product Code:
 
TAR-T36322
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T36322-1mg1mg£332.00
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Further Information

Bioactivity:
C8 D-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. It is cytotoxic to U937 cells (IC50 = 17 μM) and induces nuclear DNA fragmentation 5- to 6-fold more potently than C8 ceramide . C8 D-threo Ceramide is a substrate for E. coli diacylglycerol kinase. It activates ceramide-activated protein kinase (CAPK) in U937 cells. C8 D-threo Ceramide also enhances V. cholerae cytolysin pore formation in liposome lipid membranes, as measured by calcein release, with a 50% release dose (RD50) value of ~5 μg/ml.
CAS:
175892-43-0
Formula:
C26H51NO3
Molecular Weight:
425.7
Purity:
0.98
SMILES:
OC[C@H]([C@H](O)/C=C/CCCCCCCCCCCCC)NC(CCCCCCC)=O