TargetMol

N-Desmethyl Sildenafil

Product Code:
 
TAR-T36061
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T36061-1mg1mg£103.00
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TAR-T36061-5mg5mg£148.00
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TAR-T36061-1mL1 mL * 10 mM (in DMSO)£156.00
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TAR-T36061-10mg10mg£195.00
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TAR-T36061-25mg25mg£322.00
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TAR-T36061-50mg50mg£470.00
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TAR-T36061-100mg100mg£651.00
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TAR-T36061-500mg500mg£1,291.00
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This product comes from: United States.
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Further Information

Bioactivity:
N-Desmethyl sildenafil is a major metabolite of sildenafil . N-Desmethyl sildenafil is formed via oxidative metabolism of sildenafil by the cytochrome (CYP) P450 isoforms CYP3A4, CYP3A5, and CYP3A7.
CAS:
139755-82-1
Formula:
C21H28N6O4S
Molecular Weight:
460.55
Pathway:
Metabolism
Purity:
0.98
SMILES:
CCCc1nn(C)c2c1[nH]c(nc2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCNCC1
Target:
Drug Metabolite

References

P?ter Barab?s, et al. Sildenafil, N-desmethyl-sildenafil and Zaprinast enhance photoreceptor response in the isolated rat retina. Neurochem Int. 2003 Nov;43(6):591-5. Rikako Takahiro, et al. Contribution of CYP3A isoforms to dealkylation of PDE5 inhibitors: a comparison between sildenafil N-demethylation and tadalafil demethylenation. Biol Pharm Bull. 2015;38(1):58-65.