TargetMol

T2AA

Product Code:
 
TAR-T35719
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T35719-5mg5mg£142.00
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Quantity:
TAR-T35719-1mL1 mL * 10 mM (in DMSO)£151.00
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TAR-T35719-10mg10mg£185.00
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TAR-T35719-25mg25mg£309.00
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Quantity:
TAR-T35719-50mg50mg£462.00
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Quantity:
TAR-T35719-100mg100mg£643.00
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Quantity:
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This product comes from: United States.
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Further Information

Bioactivity:
T2AA is an inhibitor of proliferating cell nuclear antigen (PCNA) with IC50 of 1 μM for PCNA/PIP-box peptide interaction. T2AA suppresses cancer cell growth and causes DNA replication stress by stalling DNA replication forks and inhibiting PCNA interaction with DNA polymerase δ.
CAS:
1380782-27-3
Formula:
C15H15I2NO3
Molecular Weight:
511.09
Pathway:
Cell Cycle/Checkpoint; DNA Damage/DNA Repair
Purity:
0.9819
SMILES:
O(C1=C(I)C=C(C[C@@H](CO)N)C=C1I)C2=CC=C(O)C=C2
Target:
DNA/RNA Synthesis

References

Punchihewa C, et al. Identification of small molecule proliferating cell nuclear antigen (PCNA) inhibitor that disrupts interactions with PIP-box proteins and inhibits DNA replication. J Biol Chem. 2012 Apr 20;287(17):14289-300.