TargetMol

Adenosine 5?-methylenediphosphate (hydrate)

Product Code:
 
TAR-T35573
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
 

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CodeSizePrice
TAR-T35573-1mg1mg£116.00
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TAR-T35573-5mg5mg£239.00
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TAR-T35573-10mg10mg£338.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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Further Information

Bioactivity:
Adenosine 5?-methylenediphosphate is an inhibitor of ecto-5?-nucleotidase, also known as CD73, with a Kivalue of 37 nM.1It inhibits cAMP accumulation induced by adenosine 5?-monophosphate , adenosine 5?-diphosphate , or adenosine 5?-triphosphate but not adenosine in VA-13 human fibroblasts when used at a concentration of 100 μM. Adenosine 5?-methylenediphosphate reduces proliferation of U138MG glioma cells, as well as inhibits the invasion and migration of MHCC97H hepatocellular carcinoma (HCC) cells in a migration assay.2,3It increases tumor infiltration of CD3+CD8+T cells and reduces tumor growth in a K1735 murine melanoma model when administered at a dose of 400 μg/mouse.4
CAS:
0
Formula:
0
Molecular Weight:
0
Purity:
0.98
SMILES:
0

References

Braganhol, E., Tamajusuku, A.S.K., Bernardi, A., et al.Ecto-5?-nucleotidase/CD73 inhibition by quercetin in the human U138MG glioma cell lineBiochim. Biophys. Acta1770(9)1352-1359(2007) Shali, S., Yu, J., Zhang, X., et al.Ecto5? ucleotidase (CD73) is a potential target of hepatocellular carcinomaJ. Cell Physiol.234(7)10248-10259(2018) Bruns, R.F.Adenosine receptor activation by adenine nucleotides requires conversion of the nucleotides to adenosineNaunyn Schmiedebergs Arch. Pharmacol.315(1)5-13(1980) Forte, G., Sorrentino, R., Montinaro, A., et al.Inhibition of CD73 improves B cell-mediated anti-tumor immunity in a mouse model of melanomaJ. Immunol.189(5)2226-2233(2021)