TargetMol

X-376

Product Code:
 
TAR-T3550
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T3550-1mg1mg£95.00
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Quantity:
TAR-T3550-2mg2mg£105.00
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TAR-T3550-5mg5mg£142.00
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TAR-T3550-1mL1 mL * 10 mM (in DMSO)£156.00
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TAR-T3550-10mg10mg£168.00
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TAR-T3550-25mg25mg£288.00
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Quantity:
TAR-T3550-50mg50mg£432.00
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Quantity:
TAR-T3550-100mg100mg£562.00
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Quantity:
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This product comes from: United States.
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Further Information

Bioactivity:
Ensartinib (X-396) is an orally available small molecule inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with potential antineoplastic activity. Upon oral administration, X-396 binds to and inhibits ALK kinase, ALK fusion proteins, and ALK point mutation variants. Inhibition of ALK leads to the disruption of ALK-mediated signaling and eventually inhibits tumor cell growth in ALK-expressing tumor cells. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development.
CAS:
1365267-27-1
Formula:
C25H25Cl2FN6O3
Molecular Weight:
547.41
Pathway:
Angiogenesis; Tyrosine Kinase/Adaptors
Purity:
0.9829
SMILES:
C[C@@H](Oc1cc(nnc1N)C(=O)Nc1ccc(cc1)C(=O)N1CCN(C)CC1)c1c(Cl)ccc(F)c1Cl
Target:
c-Met/HGFR; ALK

References

Caccese M, et al. Current and developing therapies for the treatment of non-small cell lung cancer with ALK abnormalities: update and perspectives for clinical practice. Expert Opin Pharmacother. 2016 Dec;17(17):2253-2266.