TargetMol

Dihydrocyclosporin A

Product Code:
 
TAR-T31467
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T31467-1mg1mg£174.00
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TAR-T31467-5mg5mg£328.00
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TAR-T31467-10mg10mg£448.00
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TAR-T31467-25mg25mg£691.00
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TAR-T31467-1mL1 mL * 10 mM (in DMSO)£700.00
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TAR-T31467-50mg50mg£938.00
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TAR-T31467-100mg100mg£1,243.00
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This product comes from: United States.
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  • Further Information
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Further Information

Bioactivity:
Dihydrocyclosporin A is closely related co-metabolite of cyclosporin A. Dihydrocyclosporin A significantly inhibits promastigotes and intracellular amastigotes.
CAS:
59865-15-5
Formula:
C62H113N11O12
Molecular Weight:
1204.651
Purity:
0.98
SMILES:
[H][C@@]1([C@H](O)[C@H](C)CCCC)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C(=O)[C@H](CC)NC1=O)C(C)C

References

1. Sanglier JJ, et al. Isolation of (4R)-4-[(E)-2-butenyl]-4-methyl-L-threonine, the characteristic structural element of cyclosporins, from a blocked mutant of Tolypocladium inflatum. J Antibiot (Tokyo). 1990 Jun;43(6):707-14. 2. Zheng ZW, et al. Evaluation of in vitro antileishmanial efficacy of cyclosporin A and its non-immunosuppressive derivative, dihydrocyclosporin A. Parasit Vectors. 2020 Feb 21;13(1):94. 3. Chappell LH, et al. Dosage, timing, and route of administration of cyclosporin A and nonimmunosuppressive derivatives of dihydrocyclosporin A and cyclosporin C against Schistosoma mansoni in vivo and in vitro. 4. Chappell LH, et al. Dosage, timing, and route of administration of cyclosporin A and nonimmunosuppressive derivatives of dihydrocyclosporin A and cyclosporin C against Schistosoma mansoni in vivo and in vitro. Antimicrob Agents Chemother. 1987 Oct;31(10):1567-71.