TargetMol

Jolkinolide B

Product Code:
 
TAR-T2S1040
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T2S1040-1mg1mg£149.00
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Quantity:
TAR-T2S1040-1mL1 mL * 10 mM (in DMSO)£272.00
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TAR-T2S1040-5mg5mg£272.00
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TAR-T2S1040-10mg10mg£369.00
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TAR-T2S1040-25mg25mg£573.00
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Quantity:
TAR-T2S1040-50mg50mg£784.00
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Further Information

Bioactivity:
Jolkinolide B is a bioactive diterpene isolated from the roots of Euphorbia fischeriana Steud. Jolkinolide B induces apoptosis in cancer cells. Jolkinolide B can be used for studies on preventing and treating osteolysis.
CAS:
37905-08-1
Formula:
C20H26O4
Molecular Weight:
330.42
Pathway:
MAPK; Cytoskeletal Signaling; Apoptosis; Immunology/Inflammation; NF-κb; Stem Cells; Chromatin/Epigenetic; Proteases/Proteasome; JAK/STAT signaling; Angiogenesis; PI3K/Akt/mTOR signaling
Purity:
0.98
SMILES:
CC1=C2[C@H]3O[C@]33CC[C@@H]4C(C)(C)CCC[C@@]4(C)C3[C@H]3O[C@@]23OC1=O
Target:
ERK; IL Receptor; BCL; p38 MAPK; TNF; NF-κB; Akt; Caspase; PI3K; JAK; JNK; STAT; mTOR

References

1. Ma X, et al. Jolkinolide B inhibits RANKL-induced osteoclastogenesis by suppressing the activation NF-?B and MAPK signaling pathways. Biochem Biophys Res Commun. 2014 Mar 7;445(2):282-8. 2. Wang, J., Zhou, Y., Bai, X. et al. Jolkinolide B from Euphorbia fischeriana Steud induces apoptosis in human leukemic U937 cells through PI3K/Akt and XIAP pathways. Mol Cells 32, 451?457 (2011).