TargetMol

Ro24-7429

Product Code:
 
TAR-T28578
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T28578-1mg1mg£138.00
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TAR-T28578-5mg5mg£229.00
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TAR-T28578-1mL1 mL * 10 mM (in DMSO)£252.00
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TAR-T28578-10mg10mg£322.00
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TAR-T28578-25mg25mg£499.00
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TAR-T28578-50mg50mg£687.00
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Quantity:
TAR-T28578-100mg100mg£938.00
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  • Further Information
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Further Information

Bioactivity:
Ro24-7429 is an effective and orally active antagonist of HIV-1 transactivator protein Tat and an inhibitor of a runt-related transcription factor 1. Ro24-7429 has anti-HIV, antifibrotic, and anti-inflammatory effects.
CAS:
139339-45-0
Formula:
C14H13ClN4
Molecular Weight:
272.74
Pathway:
Proteases/Proteasome; Microbiology/Virology
Purity:
0.9985
SMILES:
CNC1=Nc2ccc(Cl)cc2C(=NC1)c1ccc[nH]1
Target:
HIV Protease

References

1. Patki AH, Lederman MM. HIV-1 Tat protein and its inhibitor Ro 24-7429 inhibit lymphocyte proliferation and induce apoptosis in peripheral blood mononuclear cells from healthy donors. Cell Immunol. 1996 Apr 10;169(1):40-6. 2. Haubrich RH, et al. A randomized trial of the activity and safety of Ro 24-7429 (Tat antagonist) versus nucleoside for human immunodeficiency virus infection. The AIDS Clinical Trials Group 213 Team. J Infect Dis. 1995 Nov;172(5):1246-52. 3. Dunne AL, et al. HIV replication in chronically infected macrophages is not inhibited by the Tat inhibitors Ro-5-3335 and Ro-24-7429. J Leukoc Biol. 1994 Sep;56(3):369-73. 4. Michael O'Hare, et al. Targeting Runt-Related Transcription Factor 1 Prevents Pulmonary Fibrosis and Reduces Expression of Severe Acute Respiratory Syndrome Coronavirus 2 Host Mediators. Am J Pathol. 2021 Jul;191(7):1193-1208.