TargetMol

Facinicline hydrochloride

Product Code:
 
TAR-T28531
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T28531-1mg1mg£148.00
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TAR-T28531-5mg5mg£269.00
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TAR-T28531-1mL1 mL * 10 mM (in DMSO)£289.00
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TAR-T28531-10mg10mg£402.00
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TAR-T28531-25mg25mg£626.00
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TAR-T28531-50mg50mg£862.00
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TAR-T28531-100mg100mg£1,139.00
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Further Information

Bioactivity:
Facinicline hydrochloride is both a novel nicotinic alpha-7 receptor (alpha7nAChR) partial agonist (Ki = 6 nM) and an antagonist of 5-HT3(Ki = 1.2 nM). Facinicline hydrochloride improves cognition and sensorimotor gating in rodents.
CAS:
677305-02-1
Formula:
C15H19ClN4O
Molecular Weight:
306.79
Pathway:
Neuroscience; GPCR/G Protein
Purity:
0.98
SMILES:
Cl.O=C(N[C@@H]1CN2CCC1CC2)c1n[nH]c2ccccc12
Target:
5-HT Receptor; AChR

References

1. Boess F, et al. Use of early phenotypic in vivo markers to assess human relevance of an unusual rodent non-genotoxic carcinogen in vitro. Toxicology. 2017 Mar 15;379:48-61. 2. Tanya L Wallace, et al. RG3487, a Novel Nicotinic ?7 Receptor Partial Agonist, Improves Cognition and Sensorimotor Gating in Rodents. J Pharmacol Exp Ther. 2011 Jan;336(1):242-53. 3. Hashimoto K. Targeting of ?7 Nicotinic Acetylcholine Receptors in the Treatment of Schizophrenia and the Use of Auditory Sensory Gating as a Translational Biomarker. Curr Pharm Des. 2015;21(26):3797-806. Review. 4. Hao Y, Tang J, Wang K. Development of Automated Patch Clamp Assay for Evaluation of ?7 Nicotinic Acetylcholine Receptor Agonists in Automated QPatch-16. Assay Drug Dev Technol. 2015 Apr;13(3):174-84.