TargetMol

Firibastat

Product Code:
 
TAR-T28482
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T28482-1mg1mg£103.00
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Quantity:
TAR-T28482-5mg5mg£148.00
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Quantity:
TAR-T28482-10mg10mg£201.00
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Quantity:
TAR-T28482-25mg25mg£329.00
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Quantity:
TAR-T28482-50mg50mg£470.00
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Quantity:
TAR-T28482-100mg100mg£651.00
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Quantity:
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
QGC-001 is a glutamyl aminopeptidase antagonist and an orally active brain penetrating prodrug of EC33. It is a first-in-class brain aminopeptidase A (APA) inhibitor with a Ki of 200 nM. QGC-001 selectively and specifically inhibits conversion of brain angiotensin-II into angiotensin-III and decreases blood pressure in hypertensive rats[1][2].
CAS:
648927-86-0
Formula:
C8H20N2O6S4
Molecular Weight:
368.5
Pathway:
Metabolism
Purity:
0.98
SMILES:
N[C@@H](CCS(O)(=O)=O)CSSC[C@@H](N)CCS(O)(=O)=O
Target:
Aminopeptidase

References

1. Ferdinand KC, et al. Efficacy and Safety of Firibastat, A First-in-Class Brain Aminopeptidase A Inhibitor, in Hypertensive Overweight Patients of Multiple Ethnic Origins. Circulation. 2019;140(2):138-146. 2. Keck M, et al. Orally Active Aminopeptidase A Inhibitor Prodrugs: Current State and Future Directions. Curr Hypertens Rep. 2019;21(7):50. Published 2019 May 21.