TargetMol

MLS1547

Product Code:
 
TAR-T28073
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T28073-5mg5mg£105.00
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TAR-T28073-10mg10mg£118.00
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TAR-T28073-1mL1 mL * 10 mM (in DMSO)£119.00
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TAR-T28073-25mg25mg£141.00
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TAR-T28073-50mg50mg£169.00
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Further Information

Bioactivity:
MLS1547 is a highly efficacious agonist of G protein-biased dopamine D2 receptor with a Ki of 1.2 μM. MLS1547 stimulates D2R G protein-mediated signaling with EC50 of 0.37 μM in a calcium mobilization assay.
CAS:
315698-36-3
Formula:
C19H19ClN4O
Molecular Weight:
354.84
Pathway:
GPCR/G Protein; Neuroscience
Purity:
0.9802
SMILES:
Oc1c(CN2CCN(CC2)c2ccccn2)cc(Cl)c2cccnc12
Target:
Dopamine Receptor

References

1. Chun LS, et al. Structure-Activity Investigation of a G Protein-Biased Agonist Reveals Molecular Determinants for Biased Signaling of the D2 Dopamine Receptor. Front Synaptic Neurosci. 2018;10:2. Published 2018 Feb 21. 2. Free RB, et al. Discovery and characterization of a G protein-biased agonist that inhibits ?-arrestin recruitment to the D2 dopamine receptor. Mol Pharmacol. 2014;86(1):96-105.