TargetMol

KGP94

Product Code:
 
TAR-T27730
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T27730-1mg1mg£163.00
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TAR-T27730-5mg5mg£269.00
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TAR-T27730-1mL1 mL * 10 mM (in DMSO)£289.00
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TAR-T27730-10mg10mg£389.00
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TAR-T27730-25mg25mg£603.00
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TAR-T27730-50mg50mg£830.00
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TAR-T27730-100mg100mg£1,099.00
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TAR-T27730-500mg500mg£2,135.00
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This product comes from: United States.
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Further Information

Bioactivity:
KGP94 is a potent, selective, and competitive inhibitor of the lysosomal endopeptidase enzyme.
CAS:
1131456-28-4
Formula:
C14H12BrN3OS
Molecular Weight:
350.23
Pathway:
Proteases/Proteasome
Purity:
0.9852
SMILES:
NC(=S)NN=C(/c1cccc(O)c1)c1cccc(Br)c1
Target:
Cysteine Protease

References

1. Dykes SS, Fasanya HO, Siemann DW. Cathepsin L secretion by host and neoplastic cells potentiates invasion. Oncotarget. 2019 Sep 17;10(53):5560-5568. 2. Sudhan DR, et al. Cathepsin L in tumor angiogenesis and its therapeutic intervention by the small molecule inhibitor KGP94. Clin Exp Metastasis. 2016 Jun;33(5):461-73. 3. Sudhan DR, et al. Cathepsin L inactivation leads to multimodal inhibition of prostate cancer cell dissemination in a preclinical bone metastasis model. Int J Cancer. 2016 Jun 1;138(11):2665-77. 4. Sudhan DR, Siemann DW. Cathepsin L inhibition by the small molecule KGP94 suppresses tumor microenvironment enhanced metastasis associated cell functions of prostate and breast cancer cells. Clin Exp Metastasis. 2013 Oct;30(7):891-902.