TargetMol

Inz-1

Product Code:
 
TAR-T27617
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T27617-1mg1mg£132.00
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TAR-T27617-5mg5mg£197.00
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TAR-T27617-1mL1 mL * 10 mM (in DMSO)£208.00
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TAR-T27617-10mg10mg£284.00
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TAR-T27617-25mg25mg£454.00
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TAR-T27617-50mg50mg£631.00
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Quantity:
TAR-T27617-100mg100mg£870.00
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Further Information

Bioactivity:
Inz-1 is an effective and fungal-selective inhibitor of mitochondrial cytochrome bc1 with IC50s of 8.092 and 45.320 μM for yeast and human. Inz-1 reverses Fluconazole or other triazole antifungals? resistance in the pathogenic fungus Candida albicans.
CAS:
897776-15-7
Formula:
C16H14N2O2
Molecular Weight:
266.3
Pathway:
Metabolism
Purity:
0.9989
SMILES:
COC(=O)Cn1nc(-c2ccccc2)c2ccccc12
Target:
P45

References

1. Benjamin M Vincent, et al. A Fungal-Selective Cytochrome Bc 1 Inhibitor Impairs Virulence and Prevents the Evolution of Drug Resistance.Cell Chem Biol. 2016 Aug 18;23(8):978-991. 1. Benjamin M. Vincent, Jean-Baptiste Langlois, Raja Srinivas, Alex K. Lancaster, Ruth Scherz-Shouval, Luke Whitesell, Bruce Tidor, Stephen L. Buchwald, Susan Lindquist. A Fungal-Selective Cytochrome bc1 Inhibitor Impairs Virulence and Prevents the Evolution of Drug Resistance. Cell Chemical Biology, Volume 23.