TargetMol

INI-43

Product Code:
 
TAR-T27612
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T27612-1mg1mg£101.00
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TAR-T27612-5mg5mg£142.00
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TAR-T27612-1mL1 mL * 10 mM (in DMSO)£149.00
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TAR-T27612-10mg10mg£185.00
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TAR-T27612-25mg25mg£303.00
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TAR-T27612-50mg50mg£436.00
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Quantity:
TAR-T27612-100mg100mg£610.00
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This product comes from: United States.
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Further Information

Bioactivity:
INI-43, an inhibitor of Nuclear Import-43, shows a significant cytotoxic effect on various cervical and oesophageal cancer cell lines by targeting Kpnβ1 and interferes with the nuclear localization of Kpnβ1 and known Kpnβ1 cargoes, NFAT, NFκB, AP-1 and NF
CAS:
881046-01-1
Formula:
C22H23N7
Molecular Weight:
385.475
Purity:
0.98
SMILES:
CN(C)CCCn1c(N)c(-c2nc3ccccc3[nH]2)c2nc3ccccc3nc12

References

1. Stelma T, Leaner VD. KPNB1-mediated nuclear import is required for motility and inflammatory transcription factor activity in cervical cancer cells. Oncotarget. 2017 May 16;8(20):32833-32847. doi: 10.18632/oncotarget.15834. PubMed PMID: 28427184; PubMed Central PMCID: PMC5464831. 2. van der Watt PJ, Chi A, Stelma T, Stowell C, Strydom E, Carden S, Angus L, Hadley K, Lang D, Wei W, Birrer MJ, Trent JO, Leaner VD. Targeting the Nuclear Import Receptor Kpn?1 as an Anticancer Therapeutic. Mol Cancer Ther. 2016 Apr;15(4):560-73. doi: 10.1158/1535-7163.MCT-15-0052. Epub 2016 Feb 1. PubMed PMID: 26832790. 3. F J Stanfield, et al. The antiviral activity of caprochlorone. Proc Soc Exp Biol Med. 1967 May;125(1):297-303.