TargetMol

BMS-986122

Product Code:
 
TAR-T26869
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T26869-1mg1mg£103.00
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TAR-T26869-1mL1 mL * 10 mM (in DMSO)£148.00
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TAR-T26869-5mg5mg£148.00
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TAR-T26869-10mg10mg£201.00
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TAR-T26869-25mg25mg£362.00
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TAR-T26869-50mg50mg£535.00
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TAR-T26869-100mg100mg£736.00
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TAR-T26869-500mg500mg£1,396.00
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Further Information

Bioactivity:
BMS 986122 is a positive allosteric modulator of μ-opioid receptors that increases β-arrestin recruitment stimulated by endomorphin 1 in U2OS-OPRM1 human osteosarcoma cells expressing μ-opioid receptors (EC50 = 3 μM).
CAS:
313669-88-4
Formula:
C16H15BrClNO3S2
Molecular Weight:
448.77
Pathway:
Endocrinology/Hormones; Neuroscience; GPCR/G Protein
Purity:
0.9842
SMILES:
COc1ccc(cc1Br)C1SCCN1S(=O)(=O)c1ccc(Cl)cc1
Target:
Opioid Receptor

References

1. Burford NT, et al. Discovery of positive allosteric modulators and silent allosteric modulators of the ?-opioid receptor. Proc Natl Acad Sci U S A. 2013;110(26):10830-10835. 2. Livingston KE, Traynor JR. Disruption of the Na+ ion binding site as a mechanism for positive allosteric modulation of the mu-opioid receptor. Proc Natl Acad Sci U S A. 2014 Dec 23;111(51):18369-74. doi: 10.1073/pnas.1415013111. PubMed PMID: 25489080; PubMed Central PMCID: PMC4280615. 3. Burford NT, Clark MJ, Wehrman TS, Gerritz SW, Banks M, O'Connell J, Traynor JR, Alt A. Discovery of positive allosteric modulators and silent allosteric modulators of the ?-opioid receptor. Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):10830-5. doi: 10.1073/pnas.1300393110. PubMed PMID: 23754417; PubMed Central PMCID: PMC3696790.