TargetMol

Auten-99 HBr

Product Code:
 
TAR-T26684
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T26684-1mg1mg£166.00
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TAR-T26684-5mg5mg£266.00
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TAR-T26684-1mL1 mL * 10 mM (in DMSO)£294.00
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TAR-T26684-10mg10mg£385.00
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TAR-T26684-25mg25mg£597.00
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TAR-T26684-50mg50mg£820.00
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TAR-T26684-100mg100mg£1,091.00
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TAR-T26684-500mg500mg£2,103.00
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Further Information

Bioactivity:
Auten-99 HBr is a myotubularin phosphatase Jumpy inhibitor exerting potent neuroprotective effects. AUTEN-99 activates autophagy in cell cultures and animal models. AUTEN-99 appears to effectively penetrate through the blood-brain barrier, and impedes the progression of neurodegenerative symptoms in Drosophila models of Parkinson?s and Huntington?s diseases. Furthermore, the molecule increases the survival of isolated neurons under normal and oxidative stress-induced conditions. Thus, AUTEN-99 serves as a potent neuroprotective drug candidate for preventing and treating diverse neurodegenerative pathologies, and may promote healthy aging.
CAS:
1049780-58-6
Formula:
C17H15BrN2S
Molecular Weight:
359.29
Pathway:
Metabolism
Purity:
0.9837
SMILES:
Br.C1CN2C=C(SC2=N1)c1ccc(cc1)-c1ccccc1
Target:
Phosphatase

References

1. Erdos Attila, Vellai Tibor. Compounds For Enhancing Autophagy.WO/2018/130863 2. Kov?cs T, Billes V, Koml?s M, Hotzi B, Manz?ger A, Tarn?ci A, Papp D, Szikszai F, Sziny?kovics J, R?cz ?, Nosz?l B, Veszelka S, Walter FR, Deli MA, Hackler L Jr, Alfoldi R, Huzian O, Puskas LG, Liliom H, T?rnok K, Schlett K, Borsy A, Welker E, Kov?cs AL, P?d?r Z, Erd?s A, Legradi A, Bjelik A, Gulya K, Guly?s B, Vellai T. The small molecule AUTEN-99 (autophagy enhancer-99) prevents the progression of neurodegenerative symptoms. Sci Rep. 2017 Feb 16;7:42014. doi: 10.1038/srep42014. PubMed PMID: 28205624; PubMed Central PMCID: PMC5311965.