TargetMol

Plinabulin

Product Code:
 
TAR-T2511
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T2511-2mg2mg£97.00
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TAR-T2511-5mg5mg£112.00
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TAR-T2511-1mL1 mL * 10 mM (in DMSO)£116.00
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TAR-T2511-10mg10mg£132.00
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TAR-T2511-25mg25mg£185.00
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TAR-T2511-50mg50mg£256.00
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TAR-T2511-100mg100mg£367.00
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Further Information

Bioactivity:
Plinabulin (NPI-2358) is a vascular disrupting agent (VDA) against tubulin-depolymerizing tumor cells ( IC50: 9.8-18 nM). Plinabulin selectively targets and binds to the colchicine-binding site of tubulin, thereby interrupting equilibrium of microtubule dynamics. This disrupts mitotic spindle assembly leading to cell cycle arrest at M phase and blockage of cell division.
CAS:
714272-27-2
Formula:
C19H20N4O2
Molecular Weight:
336.395
Pathway:
Cytoskeletal Signaling
Purity:
0.9168
SMILES:
CC(C)(C)c1[nH]cnc1C=c1/[nH]c(=O)c(=Cc2ccccc2)[nH]c1=O
Target:
Microtubule Associated

References

1. Nicholson B, et al. Anticancer Drugs, 2006, 17(1), 25-31. 2. Singh AV, et al. Blood, 2011, 117(21), 5692-5700. 3. Bertelsen LB, et al. Int J Radiat Biol, 2011, 87(11), 1126-1134.