TargetMol

PF-9184

Product Code:
 
TAR-T21738
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T21738-50mg50mgEnquire
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TAR-T21738-1mg1mg£111.00
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TAR-T21738-5mg5mg£164.00
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TAR-T21738-10mg10mg£211.00
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TAR-T21738-25mg25mg£310.00
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This product comes from: United States.
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Further Information

Bioactivity:
PF-9184 is a potent and selective inhibitor of human microsomal prostaglandin E synthase-1 (mPGES-1), IC50 =16.5 nM. PF-9184 inhibits IL-1β-induced PGE2 synthesis in vitro.
CAS:
1221971-47-6
Formula:
C21H14Cl2N2O4S
Molecular Weight:
461.32
Pathway:
GPCR/G Protein; Immunology/Inflammation
Purity:
0.98
SMILES:
O=C(NC1=CC=C(C=C1)C=2C=CC(Cl)=C(Cl)C2)C=3NS(=O)(=O)C=4C=CC=CC4C3O
Target:
Prostaglandin Receptor

References

1. Gabriel M, et, al. Distinction of microsomal prostaglandin E synthase-1 (mPGES-1) inhibition from cyclooxygenase-2 inhibition in cells using a novel, selective mPGES-1 inhibitor. Biochem Pharmacol. 2010 May 15; 79(10): 1445-54.