TargetMol

Longikaurin E

Product Code:
 
TAR-T20805
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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Further Information

Bioactivity:
Longikaurin E is a therapeutic agent for pancreatic cancer. It is isolated from Isodon adenolomus.
CAS:
77949-42-9
Formula:
C22H30O6
Molecular Weight:
390.476
Purity:
0.98
SMILES:
[H][C@@]12[C@@H](C[C@@H]3C[C@]1(C(=O)C3=C)[C@@]1(O)OC[C@]22CCCC(C)(C)[C@@]2([H])[C@@H]1O)OC(C)=O

References

1. Cheng HB, Bo Y, Shen WX, Ren XG, Tan JN, Jia ZR, Xu CL. Longikaurin E induces apoptosis of pancreatic cancer cells via modulation of the p38 and PI3K/AKT pathways by ROS. Naunyn Schmiedebergs Arch Pharmacol. 2015 Jun;388(6):623-34. doi: 10.1007/s00210-015-1107-4. Epub 2015 Mar 6. PubMed PMID: 25743573. 2. Yeoman JT, Mak VW, Reisman SE. A unified strategy to ent-kauranoid natural products: total syntheses of (-)-trichorabdal A and (-)-longikaurin E. J Am Chem Soc. 2013 Aug 14;135(32):11764-7. doi: 10.1021/ja406599a. Epub 2013 Jul 30. PubMed PMID: 23886049. 3. Ferrucci V, Boffa I, De Masi G, Zollo M. Natural compounds for pediatric cancer treatment. Naunyn Schmiedebergs Arch Pharmacol. 2016 Feb;389(2):131-49. doi: 10.1007/s00210-015-1191-5. Epub 2015 Dec 9. Review. PubMed PMID: 26650503. 4. Li LM, Li GY, Huang SX, Xiao WL, Liao X, Lou LG, Ding LS, Sun HD. Antiproliferative ent-Kauranoids from Isodon parvifolius. Planta Med. 2006 Jun;72(8):740-5. Epub 2006 May 29. PubMed PMID: 16732517.