TargetMol

Sonidegib

Product Code:
 
TAR-T1926
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T1926-5mg5mg£114.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T1926-1mL1 mL * 10 mM (in DMSO)£117.00
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Quantity:
TAR-T1926-10mg10mg£132.00
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Quantity:
TAR-T1926-25mg25mg£165.00
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Quantity:
TAR-T1926-50mg50mg£202.00
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Quantity:
TAR-T1926-100mg100mg£291.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
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This product comes from: United States.
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Further Information

Bioactivity:
LDE225 (NVP-LDE225; Erismodegib), a Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human), respectively.
CAS:
956697-53-3
Formula:
C26H26F3N3O3
Molecular Weight:
485.5
Pathway:
GPCR/G Protein; Stem Cells
Purity:
0.9997
SMILES:
C[C@H]1CN(C[C@@H](C)O1)c1ccc(NC(=O)c2cccc(-c3ccc(OC(F)(F)F)cc3)c2C)cn1
Target:
Hedgehog/Smoothened; Smo

References

1. Pan SF, et al. ACS Med. Chem. Lett., 2010, 1 (3), 130?134. 2. Fendrich V, et al. Ann Surg, 2011, 254(5), 818-23. 3. Tauchi T, et al. Arthritis Res Ther, 2012, 14(Suppl 1), O43.