TargetMol

WR99210

Product Code:
 
TAR-T17257
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T17257-50mg50mg£667.00
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TAR-T17257-100mg100mg£962.00
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This product comes from: United States.
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Further Information

Bioactivity:
WR99210 is effective against the most pyrimethamine-resistant Plasmodium falciparum strains. WR99210 is an effective inhibitor of dihydrofolate reductase (IC50:<0.075 nM).
CAS:
47326-86-3
Formula:
C14H18Cl3N5O2
Molecular Weight:
394.68
Pathway:
Microbiology/Virology; DNA Damage/DNA Repair; Metabolism; Cell Cycle/Checkpoint
Purity:
0.98
SMILES:
CC1(C)N=C(N)N=C(N)N1OCCCOc1cc(Cl)c(Cl)cc1Cl
Target:
DHFR; Antifolate; Antibacterial

References

1. Kiara SM, et al. In vitro activity of antifolate and polymorphism in dihydrofolate reductase of 2. Hastings MD, et al. Pyrimethamine and WR99210 exert opposing selection on dihydrofolatereductase from Plasmodium vivax. Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):13137-41.