TargetMol

SEC inhibitor KL-1

Product Code:
 
TAR-T16867
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T16867-1mg1mg£116.00
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TAR-T16867-5mg5mg£182.00
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TAR-T16867-1mL1 mL * 10 mM (in DMSO)£193.00
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TAR-T16867-10mg10mg£249.00
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TAR-T16867-25mg25mg£375.00
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TAR-T16867-50mg50mg£530.00
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TAR-T16867-100mg100mg£724.00
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Further Information

Bioactivity:
SEC inhibitor KL-1 exhibits a dose-dependent inhibitory effect on AFF4-CCNT1 interaction (Ki: 3.48 μM). SEC inhibitor KL-1 is a potent, selective super elongation complex (SEC) inhibitor and disrupts the interaction between the SEC scaffolding protein AFF4.
CAS:
900308-84-1
Formula:
C18H16ClNO4
Molecular Weight:
345.78
Purity:
1
SMILES:
COc1cccc(c1)C(=O)CC(=O)C(=O)Nc1cc(Cl)ccc1C

References

1. Liang K, et al. Targeting Processive Transcription Elongation via SEC Disruption for MYC-Induced CancerTherapy. Cell. 2018 Oct 18;175(3):766-779.