TargetMol

Relacorilant

Product Code:
 
TAR-T16727
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
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CodeSizePrice
TAR-T16727-1mg1mg£177.00
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TAR-T16727-5mg5mg£313.00
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TAR-T16727-1mL1 mL * 10 mM (in DMSO)£389.00
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TAR-T16727-10mg10mg£434.00
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TAR-T16727-25mg25mg£670.00
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TAR-T16727-50mg50mg£914.00
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TAR-T16727-100mg100mg£1,211.00
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Further Information

Bioactivity:
Relacorilant is a selective and orally bioavailable antagonist of glucocorticoid receptor(Ki of 7.2 nM in HepG2 TAT assay, and also shows Kis of 12, 81.2, 210 nM for rat, human and monkey glucocorticoid receptor in cell-based assay, respectively). Relacorilant has the potential for Cushing?s syndrome treatment.
CAS:
1496510-51-0
Formula:
C27H22F4N6O3S
Molecular Weight:
586.57
Pathway:
Endocrinology/Hormones
Purity:
0.99
SMILES:
Cn1cc(cn1)S(=O)(=O)N1CCC2=Cc3c(C[C@@]2(C1)C(=O)c1cc(ccn1)C(F)(F)F)cnn3-c1ccc(F)cc1
Target:
Glucocorticoid Receptor

References

1. Hunt HJ, et al. Identification of the Clinical Candidate (R)-(1-(4-Fluorophenyl)-6-((1-methyl-1H-pyrazol-4-yl)sulfonyl)-4,4a,5,6,7,8-hexahydro-1H-pyrazolo[3,4-g]isoquinolin-4a-yl)(4-(trifluoromethyl)pyridin-2-yl)methanone (CORT125134): A Selective Glucocorticoid Receptor (GR) Antagonist. J Med Chem. 2017 Apr 27;60(8):3405-3421.