TargetMol

PRX-08066

Product Code:
 
TAR-T16669
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T16669-1mg1mg£115.00
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TAR-T16669-5mg5mg£168.00
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TAR-T16669-1mL1 mL * 10 mM (in DMSO)£185.00
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TAR-T16669-10mg10mg£213.00
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TAR-T16669-25mg25mg£367.00
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TAR-T16669-50mg50mg£511.00
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Quantity:
TAR-T16669-100mg100mg£703.00
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Quantity:
TAR-T16669-500mg500mg£1,380.00
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Quantity:
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This product comes from: United States.
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Further Information

Bioactivity:
PRX-08066 is a selective 5-hydroxytryptamine receptor 2B (5-HT2BR, IC50= 3.4 nM) antagonist that induces selective vasodilation of pulmonary arteries.
CAS:
866206-54-4
Formula:
C19H17ClFN5S
Molecular Weight:
401.89
Pathway:
GPCR/G Protein; Neuroscience
Purity:
0.9804
SMILES:
Fc1ccc(CN2CCC(CC2)Nc2ncnc3sc(Cl)cc23)cc1C#N
Target:
5-HT Receptor

References

1. Porvasnik SL, et al. PRX-08066, a novel 5-hydroxytryptamine receptor 2B antagonist, reduces monocrotaline-induced pulmonary arterial hypertension and right ventricular hypertrophy in rats. J Pharmacol Exp Ther. 2010 Aug;334(2):364-72. 2. Svejda B, et al. The 5-HT(2B) receptor plays a key regulatory role in both neuroendocrine tumor cell proliferation and the modulation of the fibroblast component of the neoplastic microenvironment. Cancer. 2010 Jun 15;116(12):2902-12. 3. Warburton R.R., et al. Online University.