TargetMol

MLN-4760

Product Code:
 
TAR-T16116
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T16116-1mg1mg£221.00
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TAR-T16116-5mg5mg£389.00
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TAR-T16116-10mg10mg£550.00
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TAR-T16116-25mg25mg£836.00
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TAR-T16116-50mg50mg£1,107.00
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Quantity:
TAR-T16116-100mg100mg£1,460.00
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This product comes from: United States.
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Further Information

Bioactivity:
MLN-4760 is an angiotensin-converting (ACE2) inhibitor(human ACE2;IC50=0.44 nM). It also has excellent selectivity (>5000-fold) versus related enzymes including human testicular ACE (IC50, >100 μM) and bovine carboxypeptidase A (CPDA; IC50, 27 μM).
CAS:
305335-31-3
Formula:
C19H23Cl2N3O4
Molecular Weight:
428.31
Pathway:
Endocrinology/Hormones
Purity:
0.9905
SMILES:
CC(C)C[C@H](N[C@@H](Cc1cncn1Cc1cc(Cl)cc(Cl)c1)C(O)=O)C(O)=O
Target:
RAAS

References

1. Dales NA, et al. Substrate-based design of the first class of angiotensin-converting enzyme-related carboxypeptidase (ACE2) inhibitors. J Am Chem Soc. 2002 Oct 9;124(40):11852-3. 2. Joshi S, et al. Angiotensin converting enzyme versus angiotensin converting enzyme-2 selectivity of MLN-4760 and DX600 in human and murine bone marrow-derived cells. Eur J Pharmacol. 2016 Mar 5;774:25-33. 3. Bennion DM, et al. Activation of the Neuroprotective Angiotensin-Converting Enzyme 2 in Rat Ischemic Stroke. Hypertension. 2015 Jul;66(1):141-8.