TargetMol

ML-792

Product Code:
 
TAR-T16102
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T16102-1mg1mg£138.00
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TAR-T16102-2mg2mg£168.00
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TAR-T16102-5mg5mg£229.00
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TAR-T16102-1mL1 mL * 10 mM (in DMSO)£270.00
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TAR-T16102-10mg10mg£303.00
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TAR-T16102-25mg25mg£436.00
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TAR-T16102-50mg50mg£570.00
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TAR-T16102-100mg100mg£784.00
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Further Information

Bioactivity:
ML-792 is a specific small ubiquitin-like modifier (SUMO)-activating enzyme (SAE) inhibitor. Compared with NAE/NEDD8 and UAE/ubiquitin (IC50s of 32 μM and >100 μM, respectively), ML-792 is an effective and selective inhibitor of SAE/SUMO1 and SAE/SUMO2 in enzymatic assays (IC50s of 3 and 11 nM, respectively).
CAS:
1644342-14-2
Formula:
C21H23BrN6O5S
Molecular Weight:
551.42
Pathway:
Ubiquitination
Purity:
0.9822
SMILES:
NS(=O)(=O)OC[C@H]1C[C@H](C[C@@H]1O)Nc1ncncc1C(=O)c1ccn(Cc2cccc(Br)c2)n1
Target:
E1/E2/E3 Enzyme

References

1. He X, et al. Probing the roles of SUMOylation in cancer cell biology by using a selective SAE inhibitor. Nat Chem Biol. 2017 Nov;13(11):1164-1171.