TargetMol

LY2979165

Product Code:
 
TAR-T15812
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T15812-1mg1mg£140.00
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TAR-T15812-2mg2mg£172.00
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TAR-T15812-5mg5mg£230.00
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TAR-T15812-10mg10mg£282.00
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TAR-T15812-25mg25mg£446.00
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TAR-T15812-50mg50mg£621.00
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TAR-T15812-100mg100mg£854.00
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This product comes from: United States.
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  • Further Information
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Further Information

Bioactivity:
LY2979165 is an orthosteric agonist of mGluR2 and can be used in studies about serving as an anti-depressant.
CAS:
1311385-32-6
Formula:
C13H22N6O6S
Molecular Weight:
390.42
Pathway:
Neuroscience
Purity:
1
SMILES:
N.O.C[C@H](N)C(=O)N[C@]1(C[C@@H](Sc2ncn[nH]2)[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O
Target:
GluR

References

1. Mitul A Mehta, et al. Group II metabotropic glutamate receptor agonist prodrugs LY2979165 and LY2140023 attenuate the functional imaging response to ketamine in healthy subjects. Psychopharmacology (Berl). 2018 Jul;235(7):1875-1886. 2. Hanna L, et al. Differentiating the roles of mGlu2 and mGlu3 receptors using LY541850, an mGlu2 agonist/mGlu3 antagonist. Neuropharmacology. 2013 Mar;66:114-21. 3. Ceolin L, et al. Study of novel selective mGlu2 agonist in the temporo-ammonic input to CA1 neurons reveals reduced mGlu2 receptor expression in a Wistar substrain with an anxiety-like phenotype. J Neurosci. 2011 May 4;31(18):6721-31. 4. Liu W, et al.Pharmacogenetic analysis of the mGlu2/3 agonist LY2140023 monohydrate in the treatment of schizophrenia.Pharmacogenomics J. 2012 Jun;12(3):246-54. 5. Dominguez C, et al. Methyl substitution of 2-aminobicyclo[3.1.0]hexane 2,6-dicarboxylate (LY354740) determines functional activity at metabotropic glutamate receptors: identification of a subtype selective mGlu2 receptor agonist. J Med Chem. 2005 May 19;48(10):3605-12.