TargetMol

Luzindole

Product Code:
 
TAR-T15795
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T15795-1mg1mg£108.00
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TAR-T15795-5mg5mg£189.00
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TAR-T15795-1mL1 mL * 10 mM (in DMSO)£197.00
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TAR-T15795-10mg10mg£270.00
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TAR-T15795-25mg25mg£407.00
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TAR-T15795-50mg50mg£567.00
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TAR-T15795-100mg100mg£773.00
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TAR-T15795-500mg500mg£1,476.00
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Further Information

Bioactivity:
Luzindole is a selective melatonin receptor antagonist. Luzindole inhibits experimental autoimmune encephalomyelitis and exerts antidepressant-like activity. Luzindole preferentially targets MT2 (Mel1b) over MT1 (Mel1a) with Ki values of 10.2 and 158 nM for human MT2 and MT1, respectively.
CAS:
117946-91-5
Formula:
C19H20N2O
Molecular Weight:
292.382
Pathway:
Neuroscience; GPCR/G Protein
Purity:
0.9896
SMILES:
CC(=O)NCCc1c(Cc2ccccc2)[nH]c2ccccc12
Target:
Melatonin Receptor; MT Receptor

References

1. Dubocovich ML, et al. Melatonin receptor antagonists that differentiate between the human Mel1a and Mel1b recombinant subtypes are used to assess the pharmacological profile of the rabbit retina ML1 presynaptic heteroreceptor. Naunyn Schmiedebergs Arch Pharmacol. 1997 Mar;355(3):365-75. 2. Constantinescu CS, et al. Luzindole, a melatonin receptor antagonist, suppresses experimental autoimmune encephalomyelitis. Pathobiology. 1997;65(4):190-4. 3. Dubocovich ML Antidepressant-like activity of the melatonin receptor antagonist, luzindole (N-0774), in the mouse behavioral despair test. Eur J Pharmacol. 1990 Jul 3;182(2):313-25.